Evaluating genetic disorders
The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify...
View ArticleDna microarray based identification and mapping of balanced translocation...
Methods for detecting and mapping chromosomal rearrangements associated with various diseases using comparative genomic hybridization are disclosed. Included are methods to identify translocation...
View ArticleMultiplex (+/-) stranded arrays and assays for detecting chromosomal...
Multiplex (+/−) stranded analyses, such as array comparative genomic hybridization (aCGH), are provided for detecting chromosomal rearrangements associated with cancer and other diseases. For example,...
View ArticleCopy number variations detecting apparatus and method
A copy number variations detecting apparatus and method according to at least one embodiment of the present invention compare column vectors adjacent to each other on array comparative genomic...
View ArticleMethod for design of an oliginucleotide array
A method is provided allowing for automatic selection of enzymes to be used in protocols such as methylation profiling, chip-on-chip, and comparative genomic hybridization experiments. The method may...
View ArticleComparative genomic hybridization array method for preimplantation genetic...
A method for determining the presence of a copy number imbalance in genomic DNA of a test sample is provided. The method can separately measure hybridization of a single test sample to a first...
View ArticleEvaluating genetic disorders
The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify...
View ArticleGc wave correction for array-based comparative genomic hybridization
The present invention provides, among other things, new methods for optimizing comparative genomic hybridization (CGH) data analysis. In particular, the methods of the invention provide increased...
View ArticleMethod for analyzing nucleic acid mutation using array comparative genomic...
There is provided a method for analyzing nucleic acid mutation using an array comparative genomic hybridization technique, which reduces the false positive and the false negative and improves the...
View ArticleComparative genomic hybridization assays using immobilized oligonucleotide...
Comparative genomic hybridization assays and compositions for use in practicing the same are provided. A characteristic of the subject comparative genomic hybridization assays is that solid support...
View ArticlePredicting response to anti-cancer therapy via array comparative genomic...
Array comparative genomic hybridization classifiers, arrays comprising the classifiers, and related methods of using the same for predicting the therapeutic efficacy of anti-cancer therapy by...
View ArticleDifferentiation between brca2-associated tumours and sporadic tumours via...
Array comparative genomic hybridization classifiers, arrays comprising the classifiers and methods of using the same for differentiating between BRCA2-associated tumors and sporadic tumors by...
View ArticlePredicting benefit of anti-cancer therapy via array comparative genomic...
Array comparative genomic hybridization classifiers, arrays comprising the classifiers, and related methods of using the same for predicting the therapeutic efficacy of anti-cancer therapy by...
View ArticleBach2 repression in cells
A method for measuring the proliferation status of a cell present in a biological sample, comprising the step of measuring in the said cell the loss of BACH2 by Fluorescence after In Situ...
View ArticleMethods for predicting response to anti-cancer therapy in cancer patients
Methods for optimizing the therapeutic efficacy of anti-cancer therapy by detecting phenotypic genetic traits using comparative genomic hybridization are disclosed....
View ArticleEvaluating genetic disorders
The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify...
View ArticleDevices and methods for efficient capture of nucleic acids
The present invention relates a device for the efficient binding of nucleic acids on a microarray, comprising a reaction zone comprising a microarray, and a capture zone comprising a porous membrane...
View ArticleClustering copy-number values for segments of genomic data
Clustering methods are disclosed including a hidden Markov model (HMM) based clustering algorithm having particular applicability for identifying tumor subtypes using array comparative genomic...
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